What the FDA labels say about taking them together
Itraconazole and venetoclax
Itraconazole's FDA label of July 13, 2026 names venetoclax in its boxed warning section; the venetoclax label PlainMeds reads does not name itraconazole. The itraconazole label: “Venetoclax Contraindicated during the dose initiation and ramp-up phase in patients with CLL/SLL.”
Check it at the source: the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.); the venetoclax FDA label on DailyMed (effective May 20, 2026, AbbVie Inc.).
What does the itraconazole label say about venetoclax?
Itraconazole label, boxed warningCoadministration with venetoclax is contraindicated in patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) during the dose initiation and ramp-up phase of venetoclax.
Itraconazole label, contraindicationsCoadministration with venetoclax is contraindicated in patients with CLL/SLL during the dose initiation and ramp-up phase of venetoclax due to the potential for an increased risk of tumor lysis syndrome.
Itraconazole label, drug interactionsVenetoclax Contraindicated during the dose initiation and ramp-up phase in patients with CLL/SLL.
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
What does the venetoclax label say about itraconazole?
Venetoclax's label (effective May 20, 2026) does not name itraconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Venclexta), AbbVie Inc., effective May 20, 2026 (SPL set b118a40d-6b56-cee3-10f6-ded821a97018), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Itraconazole | Venetoclax | |
|---|---|---|
| Labeled for | Fungal infections | Leukemia, lymphoma and myeloma |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.910 per capsule 100 mg capsule | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once