What the FDA labels say about taking them together
Itraconazole and ulipristal
Itraconazole's FDA label of July 13, 2026 names ulipristal in its drug interactions section, and ulipristal's label names itraconazole too. The itraconazole label: “Concomitant drug dose reduction may be necessary. Contraceptives Dienogest Ulipristal Monitor for adverse reactions.”
Check it at the source: the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.); the ulipristal FDA label on DailyMed (effective July 20, 2026, PMI Branded Pharmaceuticals, Inc.).
What does the itraconazole label say about ulipristal?
Itraconazole label, drug interactionsContraceptives CYP3A4 inhibitors (including itraconazole) may increase systemic contraceptive hormone concentrations. Dienogest Ulipristal Monitor for adverse reactions.
Tolsura label (Mayne Pharma Commercial LLC, April 23, 2025), drug interactionsConcomitant drug dose reduction may be necessary. Contraceptives Dienogest Ulipristal Monitor for adverse reactions.
Source: FDA drug label (Tolsura, NDA208901), Mayne Pharma Commercial LLC, effective April 23, 2025 (SPL set 306352d1-9d5a-49ad-b72d-893b99546861), via openFDA
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
What does the ulipristal label say about itraconazole?
Ulipristal label, drug interactionsConcentrations of ella Associated with Co-Administered Drugs CYP3A4 inhibitors such as itraconazole or ketoconazole increase plasma concentrations of ella [see Pharmacokinetics (12.3) ].
Source: FDA drug label (Ella), PMI Branded Pharmaceuticals, Inc., effective July 20, 2026 (SPL set 2bf93d23-cddd-4613-9066-5b5fa090404b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Itraconazole | Ulipristal | |
|---|---|---|
| Labeled for | Fungal infections | Birth control |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.910 per capsule 100 mg capsule | $37.10 per tablet 30 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once