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What the FDA labels say about taking them together

Itraconazole and ubrogepant

Ubrogepant's FDA label of June 5, 2025 names itraconazole in its drug interactions section; the itraconazole labels PlainMeds reads (2) do not name ubrogepant.

Check it at the source: the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.); the ubrogepant FDA label on DailyMed (effective June 5, 2025, Allergan, Inc.).

What does the itraconazole label say about ubrogepant?

Itraconazole's label (effective July 13, 2026) and its 1 other brand-application label do not name ubrogepant in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed

What does the ubrogepant label say about itraconazole?

Ubrogepant label, drug interactions

UBRELVY should not be used with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin) [see Contraindication s ( 4 )].

Source: FDA drug label (UBRELVY), NDA211765 (Abbvie), as published by Allergan, Inc., effective June 5, 2025 (SPL set fd9f9458-fd96-4688-be3f-f77b3d1af6ab), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

11Itraconazole generic labelers
0Ubrogepant generic labelers
ItraconazoleUbrogepant
Labeled forFungal infectionsMigraine
Boxed warningYesNo
Pharmacy cost (NADAC)$0.910 per capsule 100 mg capsule$109.11 per tablet 100 mg tablet
Shortage nowA presentation being discontinuedNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?