What the FDA labels say about taking them together
Itraconazole and tolvaptan
Itraconazole's FDA label of July 13, 2026 names tolvaptan in its drug interactions section, and tolvaptan's label names itraconazole too. The itraconazole label: “Vasopressin Receptor Antagonists Conivaptan Tolvaptan Not recommended during and 2 weeks after TOLSURA treatment.”
Check it at the source: the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.); the tolvaptan FDA label on DailyMed (effective May 7, 2026, Otsuka America Pharmaceutical, Inc.).
What does the itraconazole label say about tolvaptan?
Itraconazole label, drug interactionsVasopressin Receptor Antagonists Conivaptan Tolvaptan Not recommended during and 2 weeks after SPORANOX ® treatment.
Source: FDA drug label (Tolsura, NDA208901), Mayne Pharma Commercial LLC, effective April 23, 2025 (SPL set 306352d1-9d5a-49ad-b72d-893b99546861), via openFDA
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
What does the tolvaptan label say about itraconazole?
Jynarque label (Otsuka America Pharmaceutical, Inc., November 6, 2025), warnings and precautionsInhibitors of CYP3A Concomitant use of JYNARQUE with drugs that are moderate or strong CYP3A inhibitors (e.g., ketoconazole, itraconazole, lopinavir/ritonavir, indinavir/ritonavir, ritonavir, and conivaptan) increases tolvaptan exposure [see Drug Interactions (7.1) and Clinical Pharmacology (12.3) ].
Source: FDA drug label (Jynarque, NDA204441), Otsuka America Pharmaceutical, Inc., effective November 6, 2025 (SPL set 3febc0a1-9e5a-4ce0-843d-210f21d862c4), via openFDA
Source: FDA drug label (SAMSCA), Otsuka America Pharmaceutical, Inc., effective May 7, 2026 (SPL set 5526617c-c7b9-4556-886d-729bbabbc566), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Itraconazole | Tolvaptan | |
|---|---|---|
| Labeled for | Fungal infections | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.910 per capsule 100 mg capsule | $14.57 per tablet 15 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once