What the FDA labels say about taking them together
Itraconazole and thiotepa
Thiotepa's FDA label of January 30, 2026 names itraconazole in its drug interactions section; the itraconazole labels PlainMeds reads (2) do not name thiotepa. The thiotepa label: “Avoid co-administration of strong CYP3A4 inhibitors and strong CYP3A4 inducers with TEPADINA due to the potential effects on efficacy and toxicity.”
Check it at the source: the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.); the thiotepa FDA label on DailyMed (effective January 30, 2026, Amneal Pharmaceuticals LLC).
What does the itraconazole label say about thiotepa?
Itraconazole's label (effective July 13, 2026) and its 1 other brand-application label do not name thiotepa in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
What does the thiotepa label say about itraconazole?
Thiotepa label, drug interactionsAvoid co-administration of strong CYP3A4 inhibitors (e.g., itraconazole, clarithromycin, ritonavir) and strong CYP3A4 inducers (e.g., rifampin, phenytoin) with TEPADINA due to the potential effects on efficacy and toxicity [see Clinical Pharmacology ( 12.3 ) ].
Source: FDA drug label (TEPADINA), NDA208264 (Adienne Sa), as published by Amneal Pharmaceuticals LLC, effective January 30, 2026 (SPL set 559e353c-2dc0-16ba-e054-00144ff8d46c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Itraconazole | Thiotepa | |
|---|---|---|
| Labeled for | Fungal infections | Organ transplant rejection |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.910 per capsule 100 mg capsule | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once