Itraconazole and Solifenacin Interaction
Drug interaction information between Itraconazole and Solifenacin.
Itraconazole and Solifenacin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Itraconazole and Solifenacin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole stops the body from breaking down solifenacin, which can cause the drug to build up to unsafe levels.
FDA Label Information
Solifenacin Patients with severe renal or moderate to severe hepatic impairment : Contraindicated during and 2 weeks after itraconazole treatment.
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Solifenacin Also Interacts With
- Darunavir major
- Ketoconazole minor
- Mirabegron minor
Frequently Asked Questions
What SPL severity band is on file for Itraconazole + Solifenacin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Solifenacin's 4. In the major band specifically: Itraconazole has 19 (also Isavuconazonium, Lurasidone, Pimozide, Methadone); Solifenacin has 2 (also Darunavir).
What mechanism field is on file for Itraconazole and Solifenacin?
Itraconazole stops the body from breaking down solifenacin, which can cause the drug to build up to unsafe levels.
Itraconazole carries more major-labeled pairs than Solifenacin
SPL source-record counts only. This page's band is major · classes on file: Itraconazole (Azole Antifungal); Solifenacin (Anticholinergic (Overactive Bladder)).
Itraconazole has 19 major-labeled pairs vs Solifenacin's 2.
19 major · 20 moderate · 77 minor · 116 total
- Other major peers for Itraconazole
- Isavuconazonium
- Lurasidone
- Pimozide
- Methadone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.