What the FDA labels say about taking them together
Itraconazole and silodosin
Itraconazole's FDA label of July 13, 2026 names silodosin in its drug interactions section, and silodosin's label names itraconazole too. The silodosin label: “Concomitant use of ketoconazole or other strong CYP3A4 inhibitors is therefore contraindicated.”
Check it at the source: the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.); the silodosin FDA label on DailyMed (effective April 15, 2026, Amneal Pharmaceuticals NY LLC).
What does the itraconazole label say about silodosin?
Itraconazole label, drug interactionsExamples of Concomitant Drugs Within Class: Alfuzosin Silodosin Tamsulosin; Prevention or Management: Not recommended during and 2 weeks after SPORANOX ® treatment.
Source: FDA drug label (Tolsura, NDA208901), Mayne Pharma Commercial LLC, effective April 23, 2025 (SPL set 306352d1-9d5a-49ad-b72d-893b99546861), via openFDA
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
What does the silodosin label say about itraconazole?
Silodosin label, contraindicationsCONTRAINDICATIONS Severe renal impairment (CCr < 30 mL/min) Severe hepatic impairment (Child-Pugh score ≥ 10) Concomitant administration with strong Cytochrome P450 3A4 (CYP3A4) inhibitors (e.g., ketoconazole, clarithromycin, itraconazole, ritonavir) [see Drug Interactions (7.1) ] Patients with a history of hypersensitivity to silodosin or any of the ingredients of silodosin capsules [see Adverse Reactions (6.2) and Description (11) ] Patients with severe renal impairment [Creatinine Clearance (CCr < 30 mL/min)]. ( 4 ) Patients with severe hepatic impairment (Child-Pugh score > 10). …
Silodosin label, drug interactionsUse of strong CYP3A4 inhibitors such as itraconazole or ritonavir may cause plasma concentrations of silodosin to increase.
Silodosin label, warnings and precautionsConcomitant use of ketoconazole or other strong CYP3A4 inhibitors (e.g., itraconazole, clarithromycin, ritonavir) is therefore contraindicated [see Drug Interactions (7.1) ].
Source: FDA drug label (Silodosin), Amneal Pharmaceuticals NY LLC, effective April 15, 2026 (SPL set de619e27-9384-4b86-abdc-de0557cd39e8), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Itraconazole | Silodosin | |
|---|---|---|
| Labeled for | Fungal infections | Enlarged prostate (BPH) |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.910 per capsule 100 mg capsule | $0.319 per capsule 8 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once