What the FDA labels say about taking them together
Itraconazole and ruxolitinib
Itraconazole's FDA label of July 13, 2026 names ruxolitinib in its drug interactions section; the ruxolitinib labels PlainMeds reads (2) do not name itraconazole. The itraconazole label: “Bortezomib Brentuximab-vedotin Busulfan Erlotinib Gefitinib Idelalisib Imatinib Ixabepilone Nintedanib Panobinostat Ponatinib Ruxolitinib Sonidegib Vandetanib Monitor for adverse reactions.”
Check it at the source: the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.); the ruxolitinib FDA label on DailyMed (effective July 20, 2026, Incyte Corporation).
What does the itraconazole label say about ruxolitinib?
Itraconazole label, drug interactionsExamples of Concomitant Drugs Within Class: Bortezomib Brentuximab-vedotin Busulfan Erlotinib Gefitinib Idelalisib Imatinib Ixabepilone; Prevention or Management: Nintedanib Panobinostat Ponatinib Ruxolitinib Sonidegib Tretinoin (oral) Vandetanib; Monitor for adverse reactions. Concomitant drug dose reduction may be necessary. For idelalisib, see also.
Tolsura label (Mayne Pharma Commercial LLC, April 23, 2025), drug interactionsBortezomib Brentuximab-vedotin Busulfan Erlotinib Gefitinib Idelalisib Imatinib Ixabepilone Nintedanib Panobinostat Ponatinib Ruxolitinib Sonidegib Vandetanib Monitor for adverse reactions.
Source: FDA drug label (Tolsura, NDA208901), Mayne Pharma Commercial LLC, effective April 23, 2025 (SPL set 306352d1-9d5a-49ad-b72d-893b99546861), via openFDA
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
What does the ruxolitinib label say about itraconazole?
Ruxolitinib's label (effective July 20, 2026) and its 1 other brand-application label do not name itraconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (JAKAFI), Incyte Corporation, effective July 20, 2026 (SPL set f1c82580-87ae-11e0-bc84-0002a5d5c51b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Itraconazole | Ruxolitinib | |
|---|---|---|
| Labeled for | Fungal infections | Eczema (atopic dermatitis) |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.910 per capsule 100 mg capsule | $34.01 per gram 1.5% cream |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once