Itraconazole and Ranolazine Interaction
Drug interaction information between Itraconazole and Ranolazine.
Itraconazole and Ranolazine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Itraconazole and Ranolazine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole blocks the enzymes that break down ranolazine, which can cause the heart medicine to reach dangerous levels in your body.
FDA Label Information
Cardiovascular Drugs, Miscellaneous Ivabradine Ranolazine Contraindicated during and 2 weeks after itraconazole treatment.
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Ranolazine Also Interacts With
- Ketoconazole major
- Carbamazepine major
- Clarithromycin major
- Rifampin major
- Phenytoin major
Frequently Asked Questions
What SPL severity band is on file for Itraconazole + Ranolazine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Ranolazine's 31. In the major band specifically: Itraconazole has 19 (also Isavuconazonium, Lurasidone, Pimozide, Methadone); Ranolazine has 12 (also Ketoconazole, Carbamazepine, Clarithromycin, Rifampin).
What mechanism field is on file for Itraconazole and Ranolazine?
Itraconazole blocks the enzymes that break down ranolazine, which can cause the heart medicine to reach dangerous levels in your body.
Itraconazole carries more major-labeled pairs than Ranolazine
SPL source-record counts only. This page's band is major · classes on file: Itraconazole (Azole Antifungal); Ranolazine (Late Sodium Current Inhibitor (Antianginal)).
Itraconazole has 19 major-labeled pairs vs Ranolazine's 12.
19 major · 20 moderate · 77 minor · 116 total
- Other major peers for Itraconazole
- Isavuconazonium
- Lurasidone
- Pimozide
- Methadone
12 major · 7 moderate · 12 minor · 31 total
- Other major peers for Ranolazine
- Ketoconazole
- Carbamazepine
- Clarithromycin
- Rifampin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.