What the FDA labels say about taking them together
Itraconazole and ramelteon
Itraconazole's FDA label of July 13, 2026 names ramelteon in its drug interactions section; the ramelteon label PlainMeds reads does not name itraconazole. The itraconazole label: “Antipsychotics, Anxiolytics and Hypnotics Alprazolam Aripiprazole Buspirone Diazepam Haloperidol Midazolam (IV) Quetiapine Ramelteon Risperidone Suvorexant Monitor for adverse reactions.”
Check it at the source: the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.); the ramelteon FDA label on DailyMed (effective April 15, 2026, Takeda Pharmaceuticals America, Inc.).
What does the itraconazole label say about ramelteon?
Itraconazole label, drug interactionsAntipsychotics, Anxiolytics and Hypnotics Alprazolam Aripiprazole Buspirone Cariprazine Diazepam Haloperidol Midazolam (IV) Quetiapine Ramelteon Risperidone Suvorexant Monitor for adverse reactions.
Source: FDA drug label (Tolsura, NDA208901), Mayne Pharma Commercial LLC, effective April 23, 2025 (SPL set 306352d1-9d5a-49ad-b72d-893b99546861), via openFDA
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
What does the ramelteon label say about itraconazole?
Ramelteon's label (effective April 15, 2026) does not name itraconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Rozerem), Takeda Pharmaceuticals America, Inc., effective April 15, 2026 (SPL set 9de82310-70e8-47b9-b1fc-6c6848b99455), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Itraconazole | Ramelteon | |
|---|---|---|
| Labeled for | Fungal infections | Insomnia |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.910 per capsule 100 mg capsule | $0.660 per tablet 8 mg tablet |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once