What the FDA labels say about taking them together
Itraconazole and ponatinib
Itraconazole's FDA label of July 13, 2026 names ponatinib in its drug interactions section; the ponatinib label PlainMeds reads does not name itraconazole. The itraconazole label: “… Idelalisib Imatinib Ixabepilone; Prevention or Management: Nintedanib Panobinostat Ponatinib Ruxolitinib Sonidegib Tretinoin (oral) Vandetanib; Monitor for adverse reactions. …”
Check it at the source: the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.); the ponatinib FDA label on DailyMed (effective August 14, 2026, Takeda Pharmaceuticals America, Inc.).
What does the itraconazole label say about ponatinib?
Itraconazole label, drug interactionsExamples of Concomitant Drugs Within Class: Bortezomib Brentuximab-vedotin Busulfan Erlotinib Gefitinib Idelalisib Imatinib Ixabepilone; Prevention or Management: Nintedanib Panobinostat Ponatinib Ruxolitinib Sonidegib Tretinoin (oral) Vandetanib; Monitor for adverse reactions. Concomitant drug dose reduction may be necessary. For idelalisib, see also.
Tolsura label (Mayne Pharma Commercial LLC, April 23, 2025), drug interactionsBortezomib Brentuximab-vedotin Busulfan Erlotinib Gefitinib Idelalisib Imatinib Ixabepilone Nintedanib Panobinostat Ponatinib Ruxolitinib Sonidegib Vandetanib Monitor for adverse reactions.
Source: FDA drug label (Tolsura, NDA208901), Mayne Pharma Commercial LLC, effective April 23, 2025 (SPL set 306352d1-9d5a-49ad-b72d-893b99546861), via openFDA
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
What does the ponatinib label say about itraconazole?
Ponatinib's label (effective August 14, 2026) does not name itraconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Iclusig), Takeda Pharmaceuticals America, Inc., effective August 14, 2026 (SPL set 16d804b6-4957-43ee-b18c-3b36ec37c5ac), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Itraconazole | Ponatinib | |
|---|---|---|
| Labeled for | Fungal infections | Leukemia, lymphoma and myeloma |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.910 per capsule 100 mg capsule | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once