What the FDA labels say about taking them together
Itraconazole and paricalcitol
Paricalcitol's FDA label of August 7, 2024 names itraconazole in its drug interactions section; the itraconazole labels PlainMeds reads (2) do not name paricalcitol. The paricalcitol label: “… to: boceprevir, clarithromycin, conivaptan, grapefruit juice, indinavir, itraconazole, ketoconazole, lopinavir/ritonavir, mibefradil, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, telaprevir …”
Check it at the source: the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.); the paricalcitol FDA label on DailyMed (effective August 7, 2024, AbbVie Inc.).
What does the itraconazole label say about paricalcitol?
Itraconazole's label (effective July 13, 2026) and its 1 other brand-application label do not name paricalcitol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
What does the paricalcitol label say about itraconazole?
Paricalcitol label, drug interactionsClinical Impact; Paricalcitol is partially metabolized by CYP3A. Hence, exposure of paricalcitol will increase upon coadministration with strong CYP3A inhibitors such as but not limited to: boceprevir, clarithromycin, conivaptan, grapefruit juice, indinavir, itraconazole, ketoconazole, lopinavir/ritonavir, mibefradil, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, telaprevir, telithromycin, voriconazole.
Zemplar label (AbbVie Inc., August 1, 2024), drug interactionsExamples; Boceprevir, clarithromycin, conivaptan, grapefruit juice, indinavir, itraconazole, ketoconazole, lopinavir/ritonavir, mibefradil, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, telithromycin, and voriconazole
Source: FDA drug label (Zemplar, NDA020819), AbbVie Inc., effective August 1, 2024 (SPL set 7259652f-81bc-4ad1-bba5-d01f9fac1b80), via openFDA
Source: FDA drug label (Paricalcitol, NDA207174), Accord Healthcare, Inc., effective July 30, 2024 (SPL set 2b7c7587-2042-0d9c-e054-00144ff88e88), via openFDA
Source: FDA drug label (Zemplar), AbbVie Inc., effective August 7, 2024 (SPL set 1b27c026-2d60-47b4-2a9c-ded1818f21b5), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Itraconazole | Paricalcitol | |
|---|---|---|
| Labeled for | Fungal infections | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.910 per capsule 100 mg capsule | $1.28 per capsule 1 mcg capsule |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once