What the FDA labels say about taking them together
Itraconazole and osilodrostat
Osilodrostat's FDA label of November 18, 2025 names itraconazole in its drug interactions section; the itraconazole labels PlainMeds reads (2) do not name osilodrostat. The osilodrostat label: “Concomitant use of ISTURISA with a strong CYP3A4 inhibitor may cause an increase in osilodrostat concentration and may increase the risk of ISTURISA-related adverse reactions.”
Check it at the source: the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.); the osilodrostat FDA label on DailyMed (effective November 18, 2025, Recordati Rare Diseases, Inc.).
What does the itraconazole label say about osilodrostat?
Itraconazole's label (effective July 13, 2026) and its 1 other brand-application label do not name osilodrostat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
What does the osilodrostat label say about itraconazole?
Osilodrostat label, drug interactionsCYP3A4 Inhibitors Clinical Impact: Concomitant use of ISTURISA with a strong CYP3A4 inhibitor (…) may cause an increase in osilodrostat concentration and may increase the risk of ISTURISA-related adverse reactions. Intervention: Reduce the dose of ISTURISA by half with concomitant use of a strong CYP3A4 inhibitor.
Source: FDA drug label (Isturisa), Recordati Rare Diseases, Inc., effective November 18, 2025 (SPL set f3a5ec24-63c3-4d83-b1c0-6c550fbe7ae2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Itraconazole | Osilodrostat | |
|---|---|---|
| Labeled for | Fungal infections | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.910 per capsule 100 mg capsule | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once