What the FDA labels say about taking them together
Itraconazole and naloxegol
Itraconazole's FDA label of July 13, 2026 names naloxegol in its boxed warning section, and naloxegol's label names itraconazole too. The naloxegol label: “•Use with strong CYP3A4 inhibitors is contraindicated.”
Check it at the source: the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.); the naloxegol FDA label on DailyMed (effective September 1, 2026, Averitas Pharma, Inc.).
What does the itraconazole label say about naloxegol?
Itraconazole label, boxed warningSome examples of drugs that are contraindicated for coadministration with SPORANOX ® Capsules are: methadone, disopyramide, dofetilide, dronedarone, quinidine, isavuconazole, ergot alkaloids (such as dihydroergotamine, ergometrine (ergonovine), ergotamine, methylergometrine (methylergonovine)), irinotecan, lurasidone, oral midazolam, pimozide, triazolam, felodipine, nisoldipine, ivabradine, ranolazine, eplerenone, cisapride, naloxegol, lomitapide, lovastatin, simvastatin, avanafil, ticagrelor, finerenone, voclosporin.
Itraconazole label, drug interactionsGastrointestinal Drugs Cisapride Naloxegol Contraindicated during and 2 weeks after SPORANOX ® treatment. Aprepitant Loperamide Monitor for adverse reactions.
Source: FDA drug label (Tolsura, NDA208901), Mayne Pharma Commercial LLC, effective April 23, 2025 (SPL set 306352d1-9d5a-49ad-b72d-893b99546861), via openFDA
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
What does the naloxegol label say about itraconazole?
Naloxegol label, drug interactionsConcomitant Agent: •Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin); Mechanism of Action: •Increase plasma naloxegol concentrations and may increase the risk of adverse reactions [see ].; Clinical Recommendation: •Use with strong CYP3A4 inhibitors is contraindicated [see ].
Source: FDA drug label (MOVANTIK), Averitas Pharma, Inc., effective September 1, 2026 (SPL set 28596788-b73f-4247-85fc-3105f51fff5a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Itraconazole | Naloxegol | |
|---|---|---|
| Labeled for | Fungal infections | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.910 per capsule 100 mg capsule | $14.61 per tablet 25 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once