What the FDA labels say about taking them together
Haloperidol and itraconazole
Haloperidol's FDA label (Haloperidol Decanoate) of February 19, 2025 names itraconazole in its drug interactions section, and itraconazole's label names haloperidol too. The haloperidol label: “… coadministered with haloperidol. Examples include: CYP3A4 inhibitors – alprazolam; itraconazole, ketoconazole, nefazodone, ritonavir.”
Check it at the source: the haloperidol FDA label on DailyMed (effective April 23, 2026, PD-Rx Pharmaceuticals, Inc.); the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.).
What does the haloperidol label say about itraconazole?
Haloperidol Decanoate label (Patriot Pharmaceuticals LLC, February 19, 2025), drug interactionsThe haloperidol plasma concentrations increased when a CYP3A4 and/or CYP2D6 inhibitor was coadministered with haloperidol. Examples include: CYP3A4 inhibitors – alprazolam; itraconazole, ketoconazole, nefazodone, ritonavir.
Source: FDA drug label (Haloperidol Decanoate, NDA018701), Patriot Pharmaceuticals LLC, effective February 19, 2025 (SPL set 9f0f42a8-5f7c-4be7-93ef-3ec225502cc6), via openFDA
Source: FDA drug label (Haloperidol), PD-Rx Pharmaceuticals, Inc., effective April 23, 2026 (SPL set 533b0b4c-cbd6-4ec0-a333-8b04b5b43a1d), via openFDA; the full label on DailyMed
What does the itraconazole label say about haloperidol?
Itraconazole label, drug interactionsAntipsychotics, Anxiolytics and Hypnotics Alprazolam Aripiprazole Buspirone Cariprazine Diazepam Haloperidol Midazolam (IV) Quetiapine Ramelteon Risperidone Suvorexant Monitor for adverse reactions.
Source: FDA drug label (Tolsura, NDA208901), Mayne Pharma Commercial LLC, effective April 23, 2025 (SPL set 306352d1-9d5a-49ad-b72d-893b99546861), via openFDA
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Haloperidol | Itraconazole | |
|---|---|---|
| Labeled for | Schizophrenia | Fungal infections |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $15.60 per mL 100 mg/mL vial | $0.910 per capsule 100 mg capsule |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once