What the FDA labels say about taking them together
Guanfacine and itraconazole
Itraconazole's FDA label of July 13, 2026 names guanfacine in its drug interactions section; the guanfacine label PlainMeds reads does not name itraconazole. The itraconazole label: “For sildenafil and tadalafil, see also Urologic Drugs below. Bosentan Guanfacine Monitor for adverse reactions.”
Check it at the source: the guanfacine FDA label on DailyMed (effective June 23, 2025, Takeda Pharmaceuticals America, Inc.); the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.).
What does the guanfacine label say about itraconazole?
Guanfacine's label (effective June 23, 2025) does not name itraconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Intuniv), Takeda Pharmaceuticals America, Inc., effective June 23, 2025 (SPL set b972af81-3a37-40be-9fe1-3ddf59852528), via openFDA; the full label on DailyMed
What does the itraconazole label say about guanfacine?
Itraconazole label, drug interactionsFor sildenafil and tadalafil, see also Urologic Drugs below. Bosentan Guanfacine Monitor for adverse reactions.
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Guanfacine | Itraconazole | |
|---|---|---|
| Labeled for | ADHD, High blood pressure | Fungal infections |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.147 per tablet 1 mg tablet | $0.910 per capsule 100 mg capsule |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once