Itraconazole and Fesoterodine Interaction
Drug interaction information between Itraconazole and Fesoterodine.
Itraconazole and Fesoterodine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Itraconazole and Fesoterodine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole prevents the body from getting rid of fesoterodine, leading to higher amounts of the drug in your blood.
FDA Label Information
Fesoterodine Patients with moderate to severe renal or hepatic impairment : Contraindicated during and 2 weeks after itraconazole treatment.
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Fesoterodine Also Interacts With
- Darunavir major
- Ketoconazole moderate
- Clarithromycin moderate
- Estradiol minor
- Diltiazem minor
Frequently Asked Questions
What SPL severity band is on file for Itraconazole + Fesoterodine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Fesoterodine's 15. In the major band specifically: Itraconazole has 19 (also Isavuconazonium, Lurasidone, Pimozide, Methadone); Fesoterodine has 2 (also Darunavir).
What mechanism field is on file for Itraconazole and Fesoterodine?
Itraconazole prevents the body from getting rid of fesoterodine, leading to higher amounts of the drug in your blood.
Itraconazole carries more major-labeled pairs than Fesoterodine
SPL source-record counts only. This page's band is major · classes on file: Itraconazole (Azole Antifungal); Fesoterodine (Anticholinergic (Overactive Bladder)).
Itraconazole has 19 major-labeled pairs vs Fesoterodine's 2.
19 major · 20 moderate · 77 minor · 116 total
- Other major peers for Itraconazole
- Isavuconazonium
- Lurasidone
- Pimozide
- Methadone
2 major · 2 moderate · 11 minor · 15 total
- Other major peers for Fesoterodine
- Darunavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.