What the FDA labels say about taking them together

Isotretinoin and vitamin a

Isotretinoin's FDA label of August 19, 2026 names vitamin a in its contraindications section; the vitamin a label PlainMeds reads does not name isotretinoin. The isotretinoin label: “DRUG INTERACTIONS Vitamin A: avoid concomitant use Tetracyclines: avoid concomitant use”

Check it at the source: the isotretinoin FDA label on DailyMed (effective August 19, 2026, Sun Pharmaceutical Industries, Inc.); the vitamin a FDA label on DailyMed (effective March 3, 2026, Rising Pharma Holdings, Inc.).

What does the isotretinoin label say about vitamin a?

Isotretinoin label, contraindications
ABSORICA/ABSORICA LD is contraindicated in: Pregnancy ( 8.1 ) Patients with hypersensitivity to isotretinoin (or Vitamin A) or any of its components

Isotretinoin label, drug interactions
DRUG INTERACTIONS Vitamin A: avoid concomitant use (7.1) Tetracyclines: avoid concomitant use

Isotretinoin label (Sun Pharmaceutical Industries, Inc., January 10, 2024), contraindications
Isotretinoin capsules are contraindicated in patients with hypersensitivity to isotretinoin (or Vitamin A, given the chemical similarity to isotretinoin) or to any of its components (anaphylaxis and other allergic reactions have occurred) [see Warnings and Precautions (5.14) ].

Isotretinoin label (Sun Pharmaceutical Industries, Inc., January 10, 2024), drug interactions
DRUG INTERACTIONS Vitamin A: may cause additive adverse reactions (7.1) Tetracyclines: avoid concomitant use

Source: FDA drug label (Isotretinoin, NDA021951), Sun Pharmaceutical Industries, Inc., effective January 10, 2024 (SPL set b44200ba-6672-4ea7-b151-7caec3f53c9c), via openFDA

Source: FDA drug label (Absorica LD), Sun Pharmaceutical Industries, Inc., effective August 19, 2026 (SPL set 3ef0cff8-19c1-4441-b780-fca6c7ee1615), via openFDA; the full label on DailyMed

What does the vitamin a label say about isotretinoin?

Vitamin a's label (effective March 3, 2026) does not name isotretinoin in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (AQUASOL A Parenteral), Rising Pharma Holdings, Inc., effective March 3, 2026 (SPL set 1abd66eb-6ac8-4a9e-a609-251e46ea1a27), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

13Isotretinoin generic labelers

0Vitamin a generic labelers

	Isotretinoin	Vitamin a
Labeled for	Acne	n/a
Boxed warning	Yes	No
Pharmacy cost (NADAC)	$11.94 per capsule 10 mg capsule	n/a
Shortage now	No current entry	No current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?

Isotretinoin: the full record
Vitamin a: the full record
Check more medicines together: up to five at once