What the FDA labels say about taking them together
Isotretinoin and lomitapide
Lomitapide's FDA label of March 30, 2026 names isotretinoin in its warnings and precautions section; the isotretinoin labels PlainMeds reads (2) do not name lomitapide.
Check it at the source: the isotretinoin FDA label on DailyMed (effective August 19, 2026, Sun Pharmaceutical Industries, Inc.); the lomitapide FDA label on DailyMed (effective March 30, 2026, Chiesi USA, Inc.).
What does the isotretinoin label say about lomitapide?
Isotretinoin's label (effective August 19, 2026) and its 1 other brand-application label do not name lomitapide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Absorica LD), Sun Pharmaceutical Industries, Inc., effective August 19, 2026 (SPL set 3ef0cff8-19c1-4441-b780-fca6c7ee1615), via openFDA; the full label on DailyMed
What does the lomitapide label say about isotretinoin?
Lomitapide label, warnings and precautionsExercise caution when using JUXTAPID with other medications known to have potential for hepatotoxicity, such as isotretinoin, amiodarone, acetaminophen (>4 g/day for ≥3 days/week), methotrexate, tetracyclines, and tamoxifen.
Source: FDA drug label (Juxtapid), Chiesi USA, Inc., effective March 30, 2026 (SPL set 61a0be9d-ee58-43e0-b5cb-141011835081), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Isotretinoin | Lomitapide | |
|---|---|---|
| Labeled for | Acne | High cholesterol |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $11.94 per capsule 10 mg capsule | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once