What the FDA labels say about taking them together
Isosorbide mononitrate and vardenafil
Isosorbide mononitrate's FDA label (Isosorbide Mononitrate) of August 6, 2025 names vardenafil in its contraindications section; vardenafil's label does not name isosorbide mononitrate itself but warns about its class (nitrate vasodilators). The isosorbide mononitrate label: “Do not use isosorbide mononitrate in patients who are taking certain drugs for erectile dysfunction, such as sildenafil, tadalafil, or vardenafil.”
Check it at the source: the isosorbide mononitrate FDA label on DailyMed (effective May 11, 2026, Torrent Pharmaceuticals Limited); the vardenafil FDA label on DailyMed (effective January 5, 2026, Zydus Pharmaceuticals USA Inc.).
What does the isosorbide mononitrate label say about vardenafil?
Isosorbide Mononitrate label (OMNIVIUM PHARMACEUTICALS LLC., August 6, 2025), contraindicationsDo not use isosorbide mononitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil.
Source: FDA drug label (Isosorbide Mononitrate, NDA020215), OMNIVIUM PHARMACEUTICALS LLC., effective August 6, 2025 (SPL set cdf01e14-778b-4b3f-8372-1c18f266fb98), via openFDA
Source: FDA drug label (ISOSORBIDE MONONITRATE), Torrent Pharmaceuticals Limited, effective May 11, 2026 (SPL set 0a1e317a-7b05-4d30-9bbc-1d4ccd56ba3c), via openFDA; the full label on DailyMed
What does the vardenafil label say about isosorbide mononitrate?
Vardenafil's label does not name isosorbide mononitrate itself; it warns about its class (nitrate vasodilators):
Vardenafil label, contraindicationsCONTRAINDICATIONS Administration with nitrates and nitric oxide donors ( 2.4 , 4.1 ) Administration with guanylate cyclase (GC) stimulators, such as riociguat
Vardenafil label, contraindicationsAdministration of vardenafil with nitrates (either regularly and/or intermittently) and nitric oxide donors is contraindicated [see Clinical Pharmacology ( 12.2 )].
Source: FDA drug label (VARDENAFIL), Zydus Pharmaceuticals USA Inc., effective January 5, 2026 (SPL set 5876e062-e604-42a7-99c3-5da30b8dac06), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Isosorbide mononitrate | Vardenafil | |
|---|---|---|
| Labeled for | Angina | Erectile dysfunction |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0688 per tablet 30 mg tablet | $2.79 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once