What the FDA labels say about taking them together
Isosorbide mononitrate and riociguat
Isosorbide mononitrate's FDA label (Isosorbide Mononitrate) of August 6, 2025 names riociguat in its contraindications section; riociguat's label does not name isosorbide mononitrate itself but warns about its class (nitrate vasodilators). The isosorbide mononitrate label: “Do not use isosorbide mononitrate in patients who are taking the soluble guanylate cyclase stimulator riociguat.”
Check it at the source: the isosorbide mononitrate FDA label on DailyMed (effective May 11, 2026, Torrent Pharmaceuticals Limited); the riociguat FDA label on DailyMed (effective August 13, 2026, Bayer HealthCare Pharmaceuticals Inc.).
What does the isosorbide mononitrate label say about riociguat?
Isosorbide Mononitrate label (OMNIVIUM PHARMACEUTICALS LLC., August 6, 2025), contraindicationsDo not use isosorbide mononitrate in patients who are taking the soluble guanylate cyclase stimulator riociguat.
Source: FDA drug label (Isosorbide Mononitrate, NDA020215), OMNIVIUM PHARMACEUTICALS LLC., effective August 6, 2025 (SPL set cdf01e14-778b-4b3f-8372-1c18f266fb98), via openFDA
Source: FDA drug label (ISOSORBIDE MONONITRATE), Torrent Pharmaceuticals Limited, effective May 11, 2026 (SPL set 0a1e317a-7b05-4d30-9bbc-1d4ccd56ba3c), via openFDA; the full label on DailyMed
What does the riociguat label say about isosorbide mononitrate?
Riociguat's label does not name isosorbide mononitrate itself; it warns about its class (nitrate vasodilators):
Riociguat label, drug interactionsCo-administration of Adempas with nitrates or nitric oxide donors (such as amyl nitrite) in any form is contraindicated because of hypotension [see Contraindications (4.2) and Clinical Pharmacology (12.2) ].
Riociguat label, contraindicationsCONTRAINDICATIONS Use with nitrates or nitric oxide donors in any form
Source: FDA drug label (Adempas), Bayer HealthCare Pharmaceuticals Inc., effective August 13, 2026 (SPL set 7b57509a-3d5d-41d4-8fed-1471e26372a3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Isosorbide mononitrate | Riociguat | |
|---|---|---|
| Labeled for | Angina | Pulmonary arterial hypertension |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0688 per tablet 30 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once