What the FDA labels say about taking them together
Isosorbide dinitrate and vardenafil
Isosorbide dinitrate's FDA label of March 2, 2020 names vardenafil in its contraindications section; vardenafil's label does not name isosorbide dinitrate itself but warns about its class (nitrate vasodilators). The isosorbide dinitrate label: “Do not use Isosorbide Dinitrate in patients who are taking certain drugs for erectile dysfunction, such as sildenafil, tadalafil, or vardenafil.”
Check it at the source: the isosorbide dinitrate FDA label on DailyMed (effective March 2, 2020, Oceanside Pharmaceuticals); the vardenafil FDA label on DailyMed (effective January 5, 2026, Zydus Pharmaceuticals USA Inc.).
What does the isosorbide dinitrate label say about vardenafil?
Isosorbide dinitrate label, contraindicationsDo not use Isosorbide Dinitrate in patients who are taking certain drugs for erectile dysfunction (phosphodiesterase inhibitors), such as sildenafil, tadalafil, or vardenafil.
Source: FDA drug label (Isosorbide Dinitrate), NDA012093 (Bausch), as published by Oceanside Pharmaceuticals, effective March 2, 2020 (SPL set 723d9f78-9d77-4575-af27-1aa117e6b8d7), via openFDA; the full label on DailyMed
What does the vardenafil label say about isosorbide dinitrate?
Vardenafil's label does not name isosorbide dinitrate itself; it warns about its class (nitrate vasodilators):
Vardenafil label, contraindicationsCONTRAINDICATIONS Administration with nitrates and nitric oxide donors ( 2.4 , 4.1 ) Administration with guanylate cyclase (GC) stimulators, such as riociguat
Vardenafil label, contraindicationsAdministration of vardenafil with nitrates (either regularly and/or intermittently) and nitric oxide donors is contraindicated [see Clinical Pharmacology ( 12.2 )].
Source: FDA drug label (VARDENAFIL), Zydus Pharmaceuticals USA Inc., effective January 5, 2026 (SPL set 5876e062-e604-42a7-99c3-5da30b8dac06), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Isosorbide dinitrate | Vardenafil | |
|---|---|---|
| Labeled for | Angina | Erectile dysfunction |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.154 per tablet 10 mg tablet | $2.79 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once