What the FDA labels say about taking them together
Isosorbide dinitrate and riociguat
Isosorbide dinitrate's FDA label of March 2, 2020 names riociguat in its contraindications section; riociguat's label does not name isosorbide dinitrate itself but warns about its class (nitrate vasodilators). The isosorbide dinitrate label: “Do not use Isosorbide Dinitrate in patients who are taking the soluble guanylate cyclase stimulator riociguat.”
Check it at the source: the isosorbide dinitrate FDA label on DailyMed (effective March 2, 2020, Oceanside Pharmaceuticals); the riociguat FDA label on DailyMed (effective August 13, 2026, Bayer HealthCare Pharmaceuticals Inc.).
What does the isosorbide dinitrate label say about riociguat?
Isosorbide dinitrate label, contraindicationsDo not use Isosorbide Dinitrate in patients who are taking the soluble guanylate cyclase stimulator riociguat.
Isosorbide dinitrate label, drug interactionsConcomitant use of Isosorbide Dinitrate with riociguat, a soluble guanylate cyclase stimulator, is contraindicated (see CONTRAINDICATIONS ).
Source: FDA drug label (Isosorbide Dinitrate), NDA012093 (Bausch), as published by Oceanside Pharmaceuticals, effective March 2, 2020 (SPL set 723d9f78-9d77-4575-af27-1aa117e6b8d7), via openFDA; the full label on DailyMed
What does the riociguat label say about isosorbide dinitrate?
Riociguat's label does not name isosorbide dinitrate itself; it warns about its class (nitrate vasodilators):
Riociguat label, drug interactionsCo-administration of Adempas with nitrates or nitric oxide donors (such as amyl nitrite) in any form is contraindicated because of hypotension [see Contraindications (4.2) and Clinical Pharmacology (12.2) ].
Riociguat label, contraindicationsCONTRAINDICATIONS Use with nitrates or nitric oxide donors in any form
Source: FDA drug label (Adempas), Bayer HealthCare Pharmaceuticals Inc., effective August 13, 2026 (SPL set 7b57509a-3d5d-41d4-8fed-1471e26372a3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Isosorbide dinitrate | Riociguat | |
|---|---|---|
| Labeled for | Angina | Pulmonary arterial hypertension |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.154 per tablet 10 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once