What the FDA labels say about taking them together
Isoproterenol and sotalol
Sotalol's FDA label of December 16, 2024 names isoproterenol in its drug interactions section; the isoproterenol label PlainMeds reads does not name sotalol. The sotalol label: “Beta-2-Receptor Stimulants Beta-agonists such as albuterol, terbutaline and isoproterenol may have to be administered in increased dosages when used concomitantly with sotalol.”
Check it at the source: the isoproterenol FDA label on DailyMed (effective December 16, 2025, Eugia US LLC); the sotalol FDA label on DailyMed (effective December 16, 2024, Legacy Pharma USA, Inc.).
What does the isoproterenol label say about sotalol?
Isoproterenol's label (effective December 16, 2025) does not name sotalol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Isoproterenol Hydrochloride), Eugia US LLC, effective December 16, 2025 (SPL set 3e4050e8-7d94-4ed7-951d-1ff818ddadf1), via openFDA; the full label on DailyMed
What does the sotalol label say about isoproterenol?
Sotalol label, drug interactionsBeta-2-Receptor Stimulants Beta-agonists such as albuterol, terbutaline and isoproterenol may have to be administered in increased dosages when used concomitantly with sotalol.
Source: FDA drug label (BETAPACE), Legacy Pharma USA, Inc., effective December 16, 2024 (SPL set a6a7702f-36c9-45db-b640-453dc324baee), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Isoproterenol | Sotalol | |
|---|---|---|
| Labeled for | n/a | Atrial fibrillation |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.0707 per tablet 80 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once