What the FDA labels say about taking them together
Isoproterenol and nicotine
Nicotine's FDA label of July 25, 2024 names isoproterenol in its drug interactions (prescription label) section; the isoproterenol label PlainMeds reads does not name nicotine. The nicotine label: “May Require an Increase in Dose at Cessation of Smoking Possible Mechanism Adrenergic agonists Decrease in circulating catecholamines with smoking cessation.”
Check it at the source: the isoproterenol FDA label on DailyMed (effective December 16, 2025, Eugia US LLC); the nicotine FDA label on DailyMed (effective July 25, 2024, Dr. Reddys Laboratories Inc.).
What does the isoproterenol label say about nicotine?
Isoproterenol's label (effective December 16, 2025) does not name nicotine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Isoproterenol Hydrochloride), Eugia US LLC, effective December 16, 2025 (SPL set 3e4050e8-7d94-4ed7-951d-1ff818ddadf1), via openFDA; the full label on DailyMed
What does the nicotine label say about isoproterenol?
Nicotine label, drug interactions (prescription label)May Require an Increase in Dose at Cessation of Smoking Possible Mechanism Adrenergic agonists (e.g. isoproterenol, phenylephrine) Decrease in circulating catecholamines with smoking cessation.
Source: FDA drug label (Nicotine transdermal system), Dr. Reddys Laboratories Inc., effective July 25, 2024 (SPL set e2391b29-9bac-fc09-f2a5-a3370bc4e2c3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Isoproterenol | Nicotine | |
|---|---|---|
| Labeled for | n/a | Quitting smoking |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $1.87 per patch 21 mg/24hr patch |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once