What the FDA labels say about taking them together
Isocarboxazid and meperidine
Isocarboxazid's FDA label of April 21, 2026 names meperidine in its contraindications section; meperidine's label does not name isocarboxazid itself but warns about its class (MAO inhibitors).
Check it at the source: the isocarboxazid FDA label on DailyMed (effective April 21, 2026, Lifsa Drugs LLC); the meperidine FDA label on DailyMed (effective November 29, 2025, EPIC PHARMA, LLC).
What does the isocarboxazid label say about meperidine?
Isocarboxazid label, contraindicationsMeperidine Meperidine should not be used concomitantly with MAO inhibitors or within 2- or 3-weeks following MAO therapy.
Source: FDA drug label (MARPLAN), Lifsa Drugs LLC, effective April 21, 2026 (SPL set 95fde749-44ad-4668-86c4-0ff17bca0074), via openFDA; the full label on DailyMed
What does the meperidine label say about isocarboxazid?
Meperidine's label does not name isocarboxazid itself; it warns about its class (MAO inhibitors):
Meperidine label, boxed warningConcomitant use of Meperidine Hydrochloride Tablets with Monoamine Oxidase Inhibitors (MAOIs) Concomitant use of meperidine hydrochloride tablets with monoamine oxidase inhibitors (MAOIs) can result in coma, severe respiratory depression, cyanosis, and hypotension.
Meperidine label, boxed warningUse of meperidine hydrochloride tablets with MAOIs within last 14 days is contraindicated [see Contraindications (4), Warnings and Precautions (5.8), Drug Interactions (7) ].
Source: FDA drug label (Meperidine Hydrochloride), EPIC PHARMA, LLC, effective November 29, 2025 (SPL set fae5cc34-5917-4445-9516-25f97ffca8db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Isocarboxazid | Meperidine | |
|---|---|---|
| Labeled for | Depression | Pain |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $0.157 per mL 50 mg/5 mL solution |
| Shortage now | In shortage | Listed; available |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once