What the FDA labels say about taking them together
Isocarboxazid and levomilnacipran
Levomilnacipran's FDA label of April 30, 2024 names isocarboxazid in its drug interactions section; the isocarboxazid label PlainMeds reads does not name levomilnacipran. The levomilnacipran label: “Concomitant use of SSRIs and SNRIs including FETZIMA with MAOIs increases the risk of serotonin syndrome.”
Check it at the source: the isocarboxazid FDA label on DailyMed (effective April 21, 2026, Lifsa Drugs LLC); the levomilnacipran FDA label on DailyMed (effective April 30, 2024, Allergan, Inc.).
What does the isocarboxazid label say about levomilnacipran?
Isocarboxazid's label (effective April 21, 2026) does not name levomilnacipran in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (MARPLAN), Lifsa Drugs LLC, effective April 21, 2026 (SPL set 95fde749-44ad-4668-86c4-0ff17bca0074), via openFDA; the full label on DailyMed
What does the levomilnacipran label say about isocarboxazid?
Levomilnacipran label, drug interactionsMonoamine Oxidase Inhibitors (MAOIs) Clinical Impact: Concomitant use of SSRIs and SNRIs including FETZIMA with MAOIs increases the risk of serotonin syndrome. … Administration (,), Contraindications (), and Warnings and Precautions ()]. Examples: selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue
Source: FDA drug label (Fetzima), NDA204168 (Abbvie), as published by Allergan, Inc., effective April 30, 2024 (SPL set f371258d-91b3-4b6a-ac99-434a1964c3af), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Isocarboxazid | Levomilnacipran | |
|---|---|---|
| Labeled for | Depression | Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $17.61 per unit 20-40 mg titration pak |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once