What the FDA labels say about taking them together
Isavuconazonium and sirolimus
Isavuconazonium's FDA label of April 25, 2025 names sirolimus in its drug interactions section; the sirolimus labels PlainMeds reads (4) do not name isavuconazonium. The isavuconazonium label: “Sirolimus Use with Caution Concomitant administration of CRESEMBA and sirolimus results in increase in sirolimus exposure.”
Check it at the source: the isavuconazonium FDA label on DailyMed (effective April 25, 2025, Astellas Pharma US, Inc.); the sirolimus FDA label on DailyMed (effective January 28, 2026, Glenmark Pharmaceuticals Inc., USA).
What does the isavuconazonium label say about sirolimus?
Isavuconazonium label, drug interactionsSirolimus Use with Caution Concomitant administration of CRESEMBA and sirolimus results in increase in sirolimus exposure.
Source: FDA drug label (CRESEMBA), Astellas Pharma US, Inc., effective April 25, 2025 (SPL set 8f7f73b8-586a-4df0-935f-fecd4696c16c), via openFDA; the full label on DailyMed
What does the sirolimus label say about isavuconazonium?
Sirolimus's label (effective January 28, 2026) and its 3 other brand-application labels do not name isavuconazonium in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (sirolimus), Glenmark Pharmaceuticals Inc., USA, effective January 28, 2026 (SPL set 57fb4d90-3ccb-4a69-af1e-53be83f7a504), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Isavuconazonium | Sirolimus | |
|---|---|---|
| Labeled for | n/a | Organ transplant rejection |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $114.00 per capsule 186 mg capsule | $0.723 per tablet 1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once