What the FDA labels say about taking them together
Irinotecan and panitumumab
Panitumumab's FDA label of June 23, 2026 names irinotecan in its warnings and precautions section; the irinotecan labels PlainMeds reads (2) do not name panitumumab. The panitumumab label: “As a result of the toxicities experienced, patients randomized to Vectibix, bevacizumab, and chemotherapy received a lower mean relative dose intensity of each chemotherapeutic agent over the first 24 weeks on study …”
Check it at the source: the irinotecan FDA label on DailyMed (effective May 12, 2026, Pharmacia & Upjohn Company LLC); the panitumumab FDA label on DailyMed (effective June 23, 2026, Amgen, Inc).
What does the irinotecan label say about panitumumab?
Irinotecan's label (effective May 12, 2026) and its 1 other brand-application label do not name panitumumab in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Camptosar), NDA020571 (Pfizer Inc), as published by Pharmacia & Upjohn Company LLC, effective May 12, 2026 (SPL set e518dfc6-7e93-4fee-a66c-51e1ab71c056), via openFDA; the full label on DailyMed
What does the panitumumab label say about irinotecan?
Panitumumab label, warnings and precautionsAs a result of the toxicities experienced, patients randomized to Vectibix, bevacizumab, and chemotherapy received a lower mean relative dose intensity of each chemotherapeutic agent (oxaliplatin, irinotecan, bolus 5-FU, and/or infusional 5-FU) over the first 24 weeks on study compared with those randomized to bevacizumab and chemotherapy.
Source: FDA drug label (Vectibix), Amgen, Inc, effective June 23, 2026 (SPL set e0fa4bca-f245-4d92-ae29-b0c630a315c2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Irinotecan | Panitumumab | |
|---|---|---|
| Labeled for | Colorectal cancer | Colorectal cancer |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once