What the FDA labels say about taking them together
Irbesartan and lithium
Irbesartan's FDA label of August 6, 2026 names lithium in its drug interactions section; the lithium labels PlainMeds reads (4) do not name irbesartan. The irbesartan label: “Risk of lithium toxicity.”
Check it at the source: the irbesartan FDA label on DailyMed (effective August 6, 2026, Macleods Pharmaceuticals Limited); the lithium FDA label on DailyMed (effective December 23, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the irbesartan label say about lithium?
Irbesartan label, drug interactionsRisk of lithium toxicity.
Avapro label (Sanofi-Aventis U.S. LLC, August 24, 2026), drug interactionsDRUG INTERACTIONS Lithium: Risk of lithium toxicity. ( 7 ) Nonsteroidal Anti-inflammatory Drugs (NSAIDs) and COX-2 inhibitors:
Source: FDA drug label (Avapro, NDA020757), Sanofi-Aventis U.S. LLC, effective August 24, 2026 (SPL set 7885b2a8-be4e-48ab-8113-4e6ab791eb98), via openFDA
Source: FDA drug label (Irbesartan), Macleods Pharmaceuticals Limited, effective August 6, 2026 (SPL set e8635a1c-ae06-4e23-99f7-e704f91d6f43), via openFDA; the full label on DailyMed
What does the lithium label say about irbesartan?
Lithium's label (effective December 23, 2025) and its 3 other brand-application labels do not name irbesartan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lithium Carbonate), Glenmark Pharmaceuticals Inc., USA, effective December 23, 2025 (SPL set 63b3790f-a9b5-47f4-bae1-ddf8b43c13c1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Irbesartan | Lithium | |
|---|---|---|
| Labeled for | High blood pressure, Chronic kidney disease | Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.107 per tablet 150 mg tablet | $0.104 per capsule 300 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once