Irbesartan and Lithium Interaction
Drug interaction information between Irbesartan and Lithium.
Irbesartan and Lithium have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Irbesartan and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Irbesartan can make it harder for your kidneys to remove lithium from your body, which causes lithium levels to rise. This increase can lead to dangerous side effects or toxicity.
FDA Label Information
7 DRUG INTERACTIONS Lithium: Risk of lithium toxicity. 7.2 Lithium Increases in serum lithium concentrations and lithium toxicity have been reported with concomitant use of irbesartan and lithium. Monitor lithium levels in patients receiving irbesartan and lithium.
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Irbesartan + Lithium?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Irbesartan's 2. In the moderate band specifically: Irbesartan has 1; Lithium has 23 (also Amiloride, Amiodarone, Amlodipine/Valsartan, Azilsartan).
What mechanism field is on file for Irbesartan and Lithium?
Irbesartan can make it harder for your kidneys to remove lithium from your body, which causes lithium levels to rise. This increase can lead to dangerous side effects or toxicity.
Lithium carries more major-labeled pairs than Irbesartan
SPL source-record counts only. This page's band is moderate · classes on file: Irbesartan (Angiotensin II Receptor Blocker (ARB)); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Irbesartan's 1. This page itself is in the moderate band, not the major band.
1 major · 1 moderate · 0 minor · 2 total
Irbesartan has no other moderate-band peer in this dataset besides Lithium.
2 major · 23 moderate · 65 minor · 90 total
- Other moderate peers for Lithium
- Amiloride
- Amiodarone
- Amlodipine/Valsartan
- Azilsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.