What the FDA labels say about taking them together
Ioversol and metformin
Ioversol's FDA label of December 29, 2025 names metformin in its drug interactions section; the metformin labels PlainMeds reads (3) do not name ioversol.
Check it at the source: the ioversol FDA label on DailyMed (effective December 29, 2025, Liebel-Flarsheim Company LLC); the metformin FDA label on DailyMed (effective September 3, 2026, Granules India Ltd).
What does the ioversol label say about metformin?
Ioversol label, drug interactionsDRUG INTERACTIONS 7.1 Drug-Drug Interactions Metformin In patients with renal impairment, metformin can cause lactic acidosis.
Source: FDA drug label (Optiray 320), Liebel-Flarsheim Company LLC, effective December 29, 2025 (SPL set 6cb6ca5f-b249-49b0-a9eb-8aa583da7c74), via openFDA; the full label on DailyMed
What does the metformin label say about ioversol?
Metformin's label (effective September 3, 2026) and its 2 other brand-application labels do not name ioversol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (METFORMIN HYDROCHLORIDE), Granules India Ltd, effective September 3, 2026 (SPL set 73197cb5-3e23-4ac0-b189-f9bc848bce66), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ioversol | Metformin | |
|---|---|---|
| Labeled for | n/a | Type 2 diabetes |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $0.0145 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once