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What the FDA labels say about taking them together

Iodixanol and metformin

Iodixanol's FDA label of October 10, 2025 names metformin in its drug interactions section; the metformin labels PlainMeds reads (3) do not name iodixanol.

Check it at the source: the iodixanol FDA label on DailyMed (effective October 10, 2025, GE Healthcare Inc.); the metformin FDA label on DailyMed (effective September 3, 2026, Granules India Ltd).

What does the iodixanol label say about metformin?

Iodixanol label, drug interactions

DRUG INTERACTIONS 7.1 Drug-Drug Interactions Metformin In patients with renal impairment, metformin can cause lactic acidosis.

Source: FDA drug label (Visipaque), GE Healthcare Inc., effective October 10, 2025 (SPL set e9d87b8c-7695-4c0f-8e81-000dedb5f66d), via openFDA; the full label on DailyMed

What does the metformin label say about iodixanol?

Metformin's label (effective September 3, 2026) and its 2 other brand-application labels do not name iodixanol in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (METFORMIN HYDROCHLORIDE), Granules India Ltd, effective September 3, 2026 (SPL set 73197cb5-3e23-4ac0-b189-f9bc848bce66), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

1Iodixanol generic labelers
80Metformin generic labelers
IodixanolMetformin
Labeled forn/aType 2 diabetes
Boxed warningYesYes
Pharmacy cost (NADAC)n/a$0.0145 per tablet 500 mg tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?