What the FDA labels say about taking them together
Insulin human and lithium
Insulin human's FDA label of March 7, 2025 names lithium in its drug interactions section; the lithium labels PlainMeds reads (4) do not name insulin human. The insulin human label: “Drugs that May Increase or Decrease the Blood Glucose Lowering Effect of MYXREDLIN Drugs: Alcohol, beta-blockers, clonidine, and lithium salts.”
Check it at the source: the insulin human FDA label on DailyMed (effective March 7, 2025, Baxter Healthcare Corporation); the lithium FDA label on DailyMed (effective December 23, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the insulin human label say about lithium?
Insulin human label, drug interactionsDrugs that May Increase or Decrease the Blood Glucose Lowering Effect of MYXREDLIN Drugs: Alcohol, beta-blockers, clonidine, and lithium salts.
Afrezza label (Mannkind Corporation, May 30, 2026), drug interactionsAlcohol, Beta-blockers, Clonidine, and Lithium Salts Prevention or Management Monitor blood glucose more frequently and modify AFREZZA dosage, as clinically indicated, when used concomitantly with these drugs.
Source: FDA drug label (Afrezza, BLA022472), Mannkind Corporation, effective May 30, 2026 (SPL set 29f4637b-e204-425b-b89c-7238008d8c10), via openFDA
Source: FDA drug label (Humulin R U-500 Kwikpen, BLA018780), Eli Lilly and Company, effective July 1, 2026 (SPL set b60e8dd0-1d48-4dc9-87fd-e14675255e8c), via openFDA
Source: FDA drug label (MYXREDLIN), Baxter Healthcare Corporation, effective March 7, 2025 (SPL set afca6e80-a802-49fb-a978-5fe28a173001), via openFDA; the full label on DailyMed
What does the lithium label say about insulin human?
Lithium's label (effective December 23, 2025) and its 3 other brand-application labels do not name insulin human in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lithium Carbonate), Glenmark Pharmaceuticals Inc., USA, effective December 23, 2025 (SPL set 63b3790f-a9b5-47f4-bae1-ddf8b43c13c1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Insulin human | Lithium | |
|---|---|---|
| Labeled for | Type 2 diabetes, Type 1 diabetes | Bipolar disorder |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $4.26 per mL 70-30 vial | $0.104 per capsule 300 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once