Insulin Glulisine and Glucagon Interaction
Drug interaction information between Insulin Glulisine and Glucagon.
Insulin Glulisine and Glucagon have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Insulin Glulisine and Glucagon. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Glucagon raises blood sugar by releasing stored energy, which works against the blood-sugar-lowering effect of insulin.
FDA Label Information
Drugs that May Decrease the Blood Glucose Lowering Effect of APIDRA Drugs: Atypical antipsychotics, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, phenothiazine derivatives, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones.
Insulin Glulisine Also Interacts With
- Fluoxetine moderate
- Pramlintide moderate
- Octreotide moderate
- Albuterol minor
- Clonidine minor
Glucagon Also Interacts With
- Warfarin minor
- Indomethacin minor
- Glimepiride minor
- Insulin Aspart minor
- Insulin Degludec minor
Frequently Asked Questions
What SPL severity band is on file for Insulin Glulisine + Glucagon?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Glucagon has 14 labeled pairs on file vs Insulin Glulisine's 9. In the minor band specifically: Insulin Glulisine has 6 (also Albuterol, Clonidine, Lithium, Epinephrine); Glucagon has 14 (also Warfarin, Indomethacin, Glimepiride, Insulin Aspart).
What mechanism field is on file for Insulin Glulisine and Glucagon?
Glucagon raises blood sugar by releasing stored energy, which works against the blood-sugar-lowering effect of insulin.
Glucagon's labeled portfolio outnumbers Insulin Glulisine
SPL source-record counts only. This page's band is minor · classes on file: Insulin Glulisine (Rapid-Acting Insulin); Glucagon (Glucagon (Hypoglycemia Rescue)).
0 major · 3 moderate · 6 minor · 9 total
- Other minor peers for Insulin Glulisine
- Albuterol
- Clonidine
- Lithium
- Epinephrine
0 major · 0 moderate · 14 minor · 14 total
- Other minor peers for Glucagon
- Warfarin
- Indomethacin
- Glimepiride
- Insulin Aspart
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.