Insulin Glulisine and Epinephrine Interaction
Drug interaction information between Insulin Glulisine and Epinephrine.
Insulin Glulisine and Epinephrine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Insulin Glulisine and Epinephrine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Epinephrine triggers the release of sugar into the blood, which makes it harder for insulin to do its job.
FDA Label Information
Drugs that May Decrease the Blood Glucose Lowering Effect of APIDRA Drugs: Atypical antipsychotics, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, phenothiazine derivatives, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones.
Insulin Glulisine Also Interacts With
- Fluoxetine moderate
- Pramlintide moderate
- Octreotide moderate
- Albuterol minor
- Clonidine minor
Epinephrine Also Interacts With
- Tranylcypromine major
- Carbidopa/Levodopa moderate
- Digoxin moderate
- Imipramine moderate
- Levothyroxine minor
Frequently Asked Questions
What SPL severity band is on file for Insulin Glulisine + Epinephrine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Epinephrine has 28 labeled pairs on file vs Insulin Glulisine's 9. In the minor band specifically: Insulin Glulisine has 6 (also Albuterol, Clonidine, Lithium, Glucagon); Epinephrine has 24 (also Levothyroxine, Clonidine, Theophylline, Oxytocin).
What mechanism field is on file for Insulin Glulisine and Epinephrine?
Epinephrine triggers the release of sugar into the blood, which makes it harder for insulin to do its job.
Epinephrine carries more major-labeled pairs than Insulin Glulisine
SPL source-record counts only. This page's band is minor · classes on file: Insulin Glulisine (Rapid-Acting Insulin); Epinephrine (Adrenergic Agonist).
Epinephrine has 1 major-labeled pair vs Insulin Glulisine's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 6 minor · 9 total
1 major · 3 moderate · 24 minor · 28 total
- Other minor peers for Epinephrine
- Levothyroxine
- Clonidine
- Theophylline
- Oxytocin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.