Insulin Detemir and Clozapine Interaction
Drug interaction information between Insulin Detemir and Clozapine.
Insulin Detemir and Clozapine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Insulin Detemir and Clozapine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clozapine can make your body less sensitive to insulin, which prevents the insulin from lowering your blood sugar as well as it should.
FDA Label Information
Drugs That May Decrease the Blood Glucose Lowering Effect of LEVEMIR Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones.
Insulin Detemir Also Interacts With
- Fluoxetine moderate
- Pramlintide moderate
- Octreotide moderate
- Albuterol minor
- Clonidine minor
Clozapine Also Interacts With
- Cyclobenzaprine moderate
- Diphenhydramine moderate
- Fluoxetine moderate
- Sertraline minor
- Escitalopram minor
Frequently Asked Questions
What SPL severity band is on file for Insulin Detemir + Clozapine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clozapine has 42 labeled pairs on file vs Insulin Detemir's 11. In the minor band specifically: Insulin Detemir has 8 (also Albuterol, Clonidine, Olanzapine, Lithium); Clozapine has 39 (also Sertraline, Escitalopram, Bupropion, Duloxetine).
What mechanism field is on file for Insulin Detemir and Clozapine?
Clozapine can make your body less sensitive to insulin, which prevents the insulin from lowering your blood sugar as well as it should.
Clozapine's labeled portfolio outnumbers Insulin Detemir
SPL source-record counts only. This page's band is minor · classes on file: Insulin Detemir (Long-Acting Insulin); Clozapine (Atypical Antipsychotic).
0 major · 3 moderate · 8 minor · 11 total
- Other minor peers for Insulin Detemir
- Albuterol
- Clonidine
- Olanzapine
- Lithium
0 major · 3 moderate · 39 minor · 42 total
- Other minor peers for Clozapine
- Sertraline
- Escitalopram
- Bupropion
- Duloxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.