What the FDA labels say about taking them together
Indomethacin and triamterene
Indomethacin's FDA label of December 19, 2025 names triamterene in its drug interactions section, and triamterene's label names indomethacin too. The indomethacin label: “… renal prostaglandin synthesis. It has been reported that the addition of triamterene to a maintenance schedule of indomethacin capsules resulted in reversible acute renal failure in two of four healthy volunteers. …”
Check it at the source: the indomethacin FDA label on DailyMed (effective December 19, 2025, Glenmark Pharmaceuticals Inc., USA); the triamterene FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.).
What does the indomethacin label say about triamterene?
Indomethacin label, drug interactionsDiuretics Clinical Impact: Clinical studies, as well as post-marketing observations, showed that NSAIDs reduced the natriuretic effect of loop diuretics (e.g., furosemide) and thiazide diuretics in some patients. This effect has been attributed to the NSAID inhibition of renal prostaglandin synthesis. … Intervention: Indomethacin and triamterene should not be administered together. During concomitant use of indomethacin capsules with diuretics, observe patients for signs of worsening renal function, in addition to assuring diuretic efficacy including antihypertensive effects. …
Indomethacin label, warnings and precautionsIndomethacin and triamterene should not be administered together.
Source: FDA drug label (Indomethacin), Glenmark Pharmaceuticals Inc., USA, effective December 19, 2025 (SPL set f7ed39e2-5431-4e47-935c-c7441d058f94), via openFDA; the full label on DailyMed
What does the triamterene label say about indomethacin?
Triamterene label, drug interactionsA possible interaction resulting in acute renal failure has been reported in a few subjects when indomethacin, a nonsteroidal anti-inflammatory agent, was given with triamterene.
Source: FDA drug label (Dyrenium), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set ebb177c0-d45d-4443-a85a-e76bd9931a42), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Indomethacin | Triamterene | |
|---|---|---|
| Labeled for | Rheumatoid arthritis, Osteoarthritis | Heart failure, Edema (fluid retention) |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.210 per capsule 75 mg capsule | $5.98 per capsule 50 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once