What the FDA labels say about taking them together
Indomethacin and sulfamethoxazole/trimethoprim
Sulfamethoxazole/trimethoprim's FDA label of December 30, 2024 names indomethacin in its drug interactions section; the indomethacin labels PlainMeds reads (4) do not name sulfamethoxazole/trimethoprim. The sulfamethoxazole/trimethoprim label: “Increased sulfamethoxazole blood levels may occur in patients who are also receiving indomethacin.”
Check it at the source: the indomethacin FDA label on DailyMed (effective December 19, 2025, Glenmark Pharmaceuticals Inc., USA); the sulfamethoxazole/trimethoprim FDA label on DailyMed (effective December 30, 2024, Sun Pharmaceutical Industries, Inc).
What does the indomethacin label say about sulfamethoxazole/trimethoprim?
Indomethacin's label (effective December 19, 2025) and its 3 other brand-application labels do not name sulfamethoxazole/trimethoprim in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Indomethacin), Glenmark Pharmaceuticals Inc., USA, effective December 19, 2025 (SPL set f7ed39e2-5431-4e47-935c-c7441d058f94), via openFDA; the full label on DailyMed
What does the sulfamethoxazole/trimethoprim label say about indomethacin?
Sulfamethoxazole/trimethoprim label, drug interactionsIndomethacin Avoid concurrent use Increased sulfamethoxazole blood levels may occur in patients who are also receiving indomethacin.
Source: FDA drug label (Sulfatrim, NDA018615), Preferred Pharmaceuticals, Inc., effective September 2, 2026 (SPL set cd4932ce-0856-4e99-8baf-70afce1d7ffd), via openFDA
Source: FDA drug label (Bactrim), Sun Pharmaceutical Industries, Inc, effective December 30, 2024 (SPL set f59d0c04-9c66-4d53-a0e1-cb55570deb62), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Indomethacin | Sulfamethoxazole/trimethoprim | |
|---|---|---|
| Labeled for | Rheumatoid arthritis, Osteoarthritis | Bacterial infections, Urinary tract infections, Diarrhea |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.210 per capsule 75 mg capsule | $0.0448 per tablet Sulfamethoxazole-tmp ds tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once