What the FDA labels say about taking them together
Indomethacin and pretomanid
Pretomanid's FDA label of November 15, 2024 names indomethacin in its drug interactions section; the indomethacin labels PlainMeds reads (4) do not name pretomanid. The pretomanid label: “If pretomanid is co-administered with OAT3 substrate drugs, increase monitoring for OAT3 substrate drug-related adverse reactions and consider dosage reduction for OAT3 substrate drugs, if needed.”
Check it at the source: the indomethacin FDA label on DailyMed (effective December 19, 2025, Glenmark Pharmaceuticals Inc., USA); the pretomanid FDA label on DailyMed (effective November 15, 2024, Viatris Specialty LLC).
What does the indomethacin label say about pretomanid?
Indomethacin's label (effective December 19, 2025) and its 3 other brand-application labels do not name pretomanid in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Indomethacin), Glenmark Pharmaceuticals Inc., USA, effective December 19, 2025 (SPL set f7ed39e2-5431-4e47-935c-c7441d058f94), via openFDA; the full label on DailyMed
What does the pretomanid label say about indomethacin?
Pretomanid label, drug interactionsIf pretomanid is co-administered with OAT3 substrate drugs (e.g., methotrexate, indomethacin, ciprofloxacin), increase monitoring for OAT3 substrate drug-related adverse reactions and consider dosage reduction for OAT3 substrate drugs, if needed.
Source: FDA drug label (Pretomanid), NDA212862 (Mylan Ireland Ltd), as published by Viatris Specialty LLC, effective November 15, 2024 (SPL set f1906fc9-cb3c-4e13-8a4a-da76100c1bf3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Indomethacin | Pretomanid | |
|---|---|---|
| Labeled for | Rheumatoid arthritis, Osteoarthritis | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.210 per capsule 75 mg capsule | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once