What the FDA labels say about taking them together
Indomethacin and pemetrexed
Indomethacin's FDA label of December 19, 2025 names pemetrexed in its drug interactions section; the pemetrexed labels PlainMeds reads (4) do not name indomethacin. The indomethacin label: “Concomitant use of INDOCIN and pemetrexed may increase the risk of pemetrexed-associated myelosuppression, renal, and GI toxicity.”
Check it at the source: the indomethacin FDA label on DailyMed (effective December 19, 2025, Glenmark Pharmaceuticals Inc., USA); the pemetrexed FDA label on DailyMed (effective October 8, 2025, Avyxa Pharma, LLC).
What does the indomethacin label say about pemetrexed?
Indomethacin label, drug interactionsPemetrexed Clinical Impact: Concomitant use of indomethacin capsules and pemetrexed may increase the risk of pemetrexed-associated myelosuppression, renal, and GI toxicity (…). Intervention: During concomitant use of indomethacin capsules and pemetrexed, in patients with renal impairment whose creatinine clearance ranges from 45 to 79 mL/min, monitor for myelosuppression, renal and GI toxicity. …
Source: FDA drug label (Indocin, NDA018332), Zyla Life Sciences US LLC, effective December 16, 2024 (SPL set 73878376-1d24-423b-9f37-3666e83c95da), via openFDA
Source: FDA drug label (Indomethacin), Glenmark Pharmaceuticals Inc., USA, effective December 19, 2025 (SPL set f7ed39e2-5431-4e47-935c-c7441d058f94), via openFDA; the full label on DailyMed
What does the pemetrexed label say about indomethacin?
Pemetrexed's label (effective October 8, 2025) and its 3 other brand-application labels do not name indomethacin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (AXTLE), Avyxa Pharma, LLC, effective October 8, 2025 (SPL set 9582c46c-d8b0-44b7-a2ee-9c86f5e9b7b1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Indomethacin | Pemetrexed | |
|---|---|---|
| Labeled for | Rheumatoid arthritis, Osteoarthritis | Lung cancer |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.210 per capsule 75 mg capsule | n/a |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once