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What the FDA labels say about taking them together

Inavolisib and loperamide

Inavolisib's FDA label of April 21, 2026 names loperamide in its warnings and precautions section; the loperamide label PlainMeds reads does not name inavolisib. The inavolisib label: “Advise patients to start anti-diarrheal treatment, increase oral fluids, and notify their healthcare provider if severe diarrhea occurs.”

Check it at the source: the inavolisib FDA label on DailyMed (effective April 21, 2026, Genentech, Inc.); the loperamide FDA label on DailyMed (effective June 3, 2026, Aurobindo Pharma Limited).

What does the inavolisib label say about loperamide?

Inavolisib label, warnings and precautions

Advise patients to start anti-diarrheal treatment, increase oral fluids, and notify their healthcare provider if severe diarrhea occurs.

Source: FDA drug label (Itovebi), Genentech, Inc., effective April 21, 2026 (SPL set 5de59f5b-e5db-410f-b692-658686ef4107), via openFDA; the full label on DailyMed

What does the loperamide label say about inavolisib?

Loperamide's label (effective June 3, 2026) does not name inavolisib in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Loperamide Hydrochloride), Aurobindo Pharma Limited, effective June 3, 2026 (SPL set 8e4004be-bf79-4631-9e38-c4e7b6726313), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

0Inavolisib generic labelers
95Loperamide generic labelers
InavolisibLoperamide
Labeled forn/aDiarrhea
Boxed warningNoYes
Pharmacy cost (NADAC)n/a$0.0549 per capsule 2 mg capsule
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?