What the FDA labels say about taking them together
Imipramine and trandolapril/verapamil
Trandolapril/verapamil's FDA label of January 29, 2026 names imipramine in its drug interactions section; the imipramine label PlainMeds reads does not name trandolapril/verapamil. The trandolapril/verapamil label: “Tranquilizers/Anti-Depressants Due to metabolism via the CYP enzyme system, there have been reports that verapamil may increase the concentrations of buspirone, midazolam, almotriptan and imipramine.”
Check it at the source: the imipramine FDA label on DailyMed (effective August 11, 2026, Leading Pharma, LLC); the trandolapril/verapamil FDA label on DailyMed (effective January 29, 2026, Glenmark Pharmaceuticals Inc., USA).
What does the imipramine label say about trandolapril/verapamil?
Imipramine's label (effective August 11, 2026) does not name trandolapril/verapamil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Imipramine Hydrochloride), Leading Pharma, LLC, effective August 11, 2026 (SPL set 490263ce-b4d2-428a-87da-fcd07f85499a), via openFDA; the full label on DailyMed
What does the trandolapril/verapamil label say about imipramine?
Trandolapril/verapamil label, drug interactionsTranquilizers/Anti-Depressants Due to metabolism via the CYP enzyme system, there have been reports that verapamil may increase the concentrations of buspirone, midazolam, almotriptan and imipramine.
Source: FDA drug label (Trandolapril and Verapamil Hydrochloride), Glenmark Pharmaceuticals Inc., USA, effective January 29, 2026 (SPL set 39bad727-af4c-4d20-933b-7f287e88099a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Imipramine | Trandolapril/verapamil | |
|---|---|---|
| Labeled for | Depression | High blood pressure |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0698 per tablet 10 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once