What the FDA labels say about taking them together
Imipramine and nicotine
Nicotine's FDA label of July 25, 2024 names imipramine in its drug interactions (prescription label) section; the imipramine label PlainMeds reads does not name nicotine. The nicotine label: “May Require a Decrease in Dose at Cessation of Smoking: Acetaminophen, caffeine, imipramine, oxazepam, pentazocine, propranolol, or other beta-blockers, theophylline; …”
Check it at the source: the imipramine FDA label on DailyMed (effective August 11, 2026, Leading Pharma, LLC); the nicotine FDA label on DailyMed (effective July 25, 2024, Dr. Reddys Laboratories Inc.).
What does the imipramine label say about nicotine?
Imipramine's label (effective August 11, 2026) does not name nicotine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Imipramine Hydrochloride), Leading Pharma, LLC, effective August 11, 2026 (SPL set 490263ce-b4d2-428a-87da-fcd07f85499a), via openFDA; the full label on DailyMed
What does the nicotine label say about imipramine?
Nicotine label, drug interactions (prescription label)May Require a Decrease in Dose at Cessation of Smoking: Acetaminophen, caffeine, imipramine, oxazepam, pentazocine, propranolol, or other beta-blockers, theophylline; Possible Mechanism: Deinduction of hepatic enzymes on smoking cessation.
Source: FDA drug label (Nicotine transdermal system), Dr. Reddys Laboratories Inc., effective July 25, 2024 (SPL set e2391b29-9bac-fc09-f2a5-a3370bc4e2c3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Imipramine | Nicotine | |
|---|---|---|
| Labeled for | Depression | Quitting smoking |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0698 per tablet 10 mg tablet | $1.87 per patch 21 mg/24hr patch |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once