What the FDA labels say about taking them together
Imatinib and ponatinib
Ponatinib's FDA label of August 14, 2026 names imatinib in its warnings and precautions section; the imatinib labels PlainMeds reads (3) do not name ponatinib. The ponatinib label: “… increased the risk of serious adverse reactions 2-fold compared to single agent imatinib 400 mg once daily.”
Check it at the source: the imatinib FDA label on DailyMed (effective September 8, 2026, Apotex Corp); the ponatinib FDA label on DailyMed (effective August 14, 2026, Takeda Pharmaceuticals America, Inc.).
What does the imatinib label say about ponatinib?
Imatinib's label (effective September 8, 2026) and its 2 other brand-application labels do not name ponatinib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Imatinib Mesylate), Apotex Corp, effective September 8, 2026 (SPL set 0291eca5-7a1d-4a79-30be-252224d96509), via openFDA; the full label on DailyMed
What does the ponatinib label say about imatinib?
Ponatinib label, warnings and precautionsToxicity in Newly Diagnosed Chronic Phase CML In a prospective randomized clinical trial in the first line treatment of newly diagnosed patients with CP-CML, single agent ICLUSIG 45 mg once daily increased the risk of serious adverse reactions 2-fold compared to single agent imatinib 400 mg once daily.
Source: FDA drug label (Iclusig), Takeda Pharmaceuticals America, Inc., effective August 14, 2026 (SPL set 16d804b6-4957-43ee-b18c-3b36ec37c5ac), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Imatinib | Ponatinib | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | Leukemia, lymphoma and myeloma |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.624 per tablet 100 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once