What the FDA labels say about taking them together
Ifosfamide and mesna
Ifosfamide's FDA label of December 2, 2024 names mesna in its boxed warning section; the mesna labels PlainMeds reads (2) do not name ifosfamide. The ifosfamide label: “Administer mesna with IFEX to reduce the incidence and severity of urotoxicity.”
Check it at the source: the ifosfamide FDA label on DailyMed (effective December 2, 2024); the mesna FDA label on DailyMed (effective December 17, 2018, Baxter Healthcare Company).
What does the ifosfamide label say about mesna?
Ifosfamide label, boxed warningHemorrhagic cystitis can be severe and can be reduced by the prophylactic use of mesna [see Warnings and Precautions (5.3) ].
Ifosfamide label, warnings and precautionsAdminister mesna with IFEX to reduce the incidence and severity of urotoxicity [see Dosage and Administration (2.1) ].
Source: FDA drug label (IFEX), Baxter Healthcare Corporation, effective December 2, 2024 (SPL set b7241707-7538-4d1a-91e7-3a25a91e0b9a), via openFDA; the full label on DailyMed
What does the mesna label say about ifosfamide?
Mesna's label (effective December 17, 2018) and its 1 other brand-application label do not name ifosfamide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (MESNA), Baxter Healthcare Company, effective December 17, 2018 (SPL set a880160b-fa82-453a-a971-29ab897876a7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ifosfamide | Mesna | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once