What the FDA labels say about taking them together
Ibuprofen and ivacaftor/lumacaftor
Ivacaftor/lumacaftor's FDA label of March 24, 2026 names ibuprofen in its drug interactions section; the ibuprofen labels PlainMeds reads (2) do not name ivacaftor/lumacaftor. The ivacaftor/lumacaftor label: “Concomitant use of ORKAMBI may reduce the exposure and effectiveness of ibuprofen.”
Check it at the source: the ibuprofen FDA label on DailyMed (effective January 1, 2026, Savings Distributors LLC); the ivacaftor/lumacaftor FDA label on DailyMed (effective March 24, 2026, Vertex Pharmaceuticals Incorporated).
What does the ibuprofen label say about ivacaftor/lumacaftor?
Ibuprofen's label (effective January 1, 2026) and its 1 other brand-application label do not name ivacaftor/lumacaftor in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Motrin IB), NDA019012 (Kenvue Brands), as published by Savings Distributors LLC, effective January 1, 2026 (SPL set 56846774-8413-c306-e063-6394a90a2be8), via openFDA; the full label on DailyMed
What does the ivacaftor/lumacaftor label say about ibuprofen?
Ivacaftor/lumacaftor label, drug interactionsConcomitant use of ORKAMBI may reduce the exposure and effectiveness of ibuprofen.
Source: FDA drug label (ORKAMBI), Vertex Pharmaceuticals Incorporated, effective March 24, 2026 (SPL set 3fc1c40e-cfac-47a1-9e1a-61ead3570600), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ibuprofen | Ivacaftor/lumacaftor | |
|---|---|---|
| Labeled for | Fever, Osteoarthritis, Rheumatoid arthritis, Pain, Cough and cold | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0573 per tablet 800 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once