What the FDA labels say about taking them together
Ibuprofen and ibuprofen lysine
Ibuprofen lysine's FDA label of October 15, 2024 names ibuprofen in its drug interactions section; ibuprofen's label does not name ibuprofen lysine itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)). The ibuprofen lysine label: “DRUG INTERACTIONS Diuretics: Ibuprofen may reduce the effect of diuretics; diuretics can increase the risk of nephrotoxicity of NSAIDs in dehydrated patients.”
Check it at the source: the ibuprofen FDA label on DailyMed (effective January 1, 2026, Savings Distributors LLC); the ibuprofen lysine FDA label on DailyMed (effective October 15, 2024, Recordati Rare Diseases Inc.).
What does the ibuprofen label say about ibuprofen lysine?
Ibuprofen's label does not name ibuprofen lysine itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)):
Ibuprofen label, boxed warningThis risk may occur early in treatment and may increase with duration of use. ( 5.1 ) CALDOLOR is contraindicated in the setting of coronary artery bypass graft (CABG) surgery. ( 4 , 5.1 ) NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.
Ibuprofen label, boxed warningGastrointestinal Bleeding, Ulceration and Perforation NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.
Source: FDA drug label (Motrin IB), NDA019012 (Kenvue Brands), as published by Savings Distributors LLC, effective January 1, 2026 (SPL set 56846774-8413-c306-e063-6394a90a2be8), via openFDA; the full label on DailyMed
What does the ibuprofen lysine label say about ibuprofen?
Ibuprofen lysine label, drug interactionsDRUG INTERACTIONS Diuretics: Ibuprofen may reduce the effect of diuretics; diuretics can increase the risk of nephrotoxicity of NSAIDs in dehydrated patients.
Ibuprofen lysine label, warnings and precautionsWARNINGS AND PRECAUTIONS NeoProfen has not been assessed for neurodevelopmental outcome and growth ( 5.1 ) NeoProfen may alter the usual signs of infection ( 5.2 ) NeoProfen can inhibit platelet aggregation, and has been shown to prolong bleeding time in normal adult subjects ( 5.3 ) Ibuprofen has been shown to displace bilirubin from albumin binding-sites ( 5.4 ) NeoProfen should be administered carefully to avoid extravascular injection or leakage ( 5.5 ) NeoProfen may cause serious skin reactions
Source: FDA drug label (NEOPROFEN), Recordati Rare Diseases Inc., effective October 15, 2024 (SPL set 6f5ede6f-b0b7-4fc8-969e-652f60ead047), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ibuprofen | Ibuprofen lysine | |
|---|---|---|
| Labeled for | Fever, Osteoarthritis, Rheumatoid arthritis, Pain, Cough and cold | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0573 per tablet 800 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once