What the FDA labels say about taking them together
Hydroxychloroquine and mefloquine
Hydroxychloroquine's FDA label of October 8, 2024 names mefloquine in its drug interactions section; the mefloquine label PlainMeds reads does not name hydroxychloroquine. The hydroxychloroquine label: “Co-administration of SOVUNA with other antimalarials known to lower the seizure threshold (e.g., mefloquine) may increase the risk of seizures.”
Check it at the source: the hydroxychloroquine FDA label on DailyMed (effective October 8, 2024, ANI Pharmaceuticals, Inc.); the mefloquine FDA label on DailyMed (effective November 18, 2024, Chartwell RX, LLC).
What does the hydroxychloroquine label say about mefloquine?
Hydroxychloroquine label, drug interactionsCo-administration of SOVUNA with other antimalarials known to lower the seizure threshold (e.g., mefloquine) may increase the risk of seizures.
Source: FDA drug label (Plaquenil, NDA009768), Advanz Pharma (US) Corp., effective April 9, 2026 (SPL set 34496b43-05a2-45fb-a769-52b12e099341), via openFDA
Source: FDA drug label (SOVUNA), ANI Pharmaceuticals, Inc., effective October 8, 2024 (SPL set dd441154-b196-4d4c-bc56-2e37f345ef8d), via openFDA; the full label on DailyMed
What does the mefloquine label say about hydroxychloroquine?
Mefloquine's label (effective November 18, 2024) does not name hydroxychloroquine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Mefloquine Hydrochloride), Chartwell RX, LLC, effective November 18, 2024 (SPL set b884d22b-aae7-4f14-9a04-ae4029a229f0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Hydroxychloroquine | Mefloquine | |
|---|---|---|
| Labeled for | Rheumatoid arthritis | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.149 per tablet 200 mg tablet | $3.97 per tablet 250 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once