What the FDA labels say about taking them together
Hydrocortisone and rifampin
Hydrocortisone's FDA label (Solu-Cortef) of August 27, 2026 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name hydrocortisone. The hydrocortisone label: “Hepatic Enzyme Inducers: Drugs that induce cytochrome P450 3A4 enzyme activity may enhance the metabolism of corticosteroids and require that the dosage of the corticosteroid be increased.”
Check it at the source: the hydrocortisone FDA label on DailyMed (effective August 19, 2026); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the hydrocortisone label say about rifampin?
Solu-Cortef label (Pharmacia & Upjohn Company LLC, August 27, 2026), drug interactionsHepatic Enzyme Inducers (e.g., barbiturates, phenytoin, carbamazepine, rifampin): Drugs that induce cytochrome P450 3A4 enzyme activity may enhance the metabolism of corticosteroids and require that the dosage of the corticosteroid be increased.
Source: FDA drug label (Solu-Cortef, NDA009866), Pharmacia & Upjohn Company LLC, effective August 27, 2026 (SPL set 65eefd58-b166-4d71-ade6-45c8fdf86922), via openFDA
Source: FDA drug label (hydrocortisone 1), Kroger Company, effective August 19, 2026 (SPL set f05edff2-2dc5-427c-b52c-518e0aaef4e0), via openFDA; the full label on DailyMed
What does the rifampin label say about hydrocortisone?
Rifampin's label (effective February 11, 2026) does not name hydrocortisone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Hydrocortisone | Rifampin | |
|---|---|---|
| Labeled for | Osteoarthritis, Asthma, Allergies, Herpes and shingles, Leukemia, lymphoma and myeloma, Crohn's disease and ulcerative colitis, Eczema (atopic dermatitis) | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0613 per gram 1% cream | $0.679 per capsule 300 mg capsule |
| Shortage now | A presentation being discontinued | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once