What the FDA labels say about taking them together
Hydrocortisone and isoniazid
Hydrocortisone's FDA label (Solu-Cortef) of August 27, 2026 names isoniazid in its drug interactions section; the isoniazid label PlainMeds reads does not name hydrocortisone. The hydrocortisone label: “Antitubercular drugs: Serum concentrations of isoniazid may be decreased.”
Check it at the source: the hydrocortisone FDA label on DailyMed (effective August 19, 2026); the isoniazid FDA label on DailyMed (effective July 8, 2025, OMNIVIUM PHARMACEUTICALS LLC.).
What does the hydrocortisone label say about isoniazid?
Solu-Cortef label (Pharmacia & Upjohn Company LLC, August 27, 2026), drug interactionsAntitubercular drugs: Serum concentrations of isoniazid may be decreased.
Source: FDA drug label (Solu-Cortef, NDA009866), Pharmacia & Upjohn Company LLC, effective August 27, 2026 (SPL set 65eefd58-b166-4d71-ade6-45c8fdf86922), via openFDA
Source: FDA drug label (hydrocortisone 1), Kroger Company, effective August 19, 2026 (SPL set f05edff2-2dc5-427c-b52c-518e0aaef4e0), via openFDA; the full label on DailyMed
What does the isoniazid label say about hydrocortisone?
Isoniazid's label (effective July 8, 2025) does not name hydrocortisone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (isoniazid), OMNIVIUM PHARMACEUTICALS LLC., effective July 8, 2025 (SPL set 35400f1d-fd25-4bfa-a382-ac390e21bf2e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Hydrocortisone | Isoniazid | |
|---|---|---|
| Labeled for | Osteoarthritis, Asthma, Allergies, Herpes and shingles, Leukemia, lymphoma and myeloma, Crohn's disease and ulcerative colitis, Eczema (atopic dermatitis) | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0613 per gram 1% cream | $3.40 per tablet 300 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once